Petra Klinge, MD, Ph.D
Associate Professor of Neurosurgery, The Warren Alpert Medical School of Brown University
Dr. Petra M. Klinge received her medical degree (MD) at the University in Kiel, Germany in 1993. After completing her neurosurgical residency at Hannover Medical School, Germany in 2002, Dr. Klinge held the position of Senior Physician and Assistant Professor of Neurosurgery at the International Neuroscience Institute in Hannover, Germany, where she joined Madjid Samii, M.D., a world-renowned and internationally acknowledged neurosurgeon. At that time, Dr. Klinge was appointed a teaching professor and in 2008 was awarded the full academic rank of an Associate Professor at the Hannover Medical School.
Dr. Klinge joined the Neurosurgery Foundation and The Warren Alpert Medical School of Brown University as an attending neurosurgeon in May 2009. She will continue her research activities within the department. Her clinical research will focus on the unifying concept of dementias, particularly Alzheimer-related pathology in hydrocephalus of aging patients. As a novel approach, she aims at establishing surgical therapies, e.g. stem-cell treatment, for treatment of stroke and other neurodegenerative diseases associated with dementia.
Dr. Klinge is an internationally renowned clinician for the diagnosis and neurosurgical treatment of patients with hydrocephalus and Alzheimer’s disease. Pediatric hydrocephalus disorders also comprise another large part of her clinical practice. From her clinical work at the International Neuroscience Institute in Hannover, she has developed outstanding expertise in the diagnosis and management of the most difficult and rare diseases of the nervous system and the spine .In addition to complex adult and pediatric hydrocephalus, her practice also includes patients with associated developmental Cerebrospinal fluid disorders, such as spina bifida, Chiari malformation as well as both benign and malignant tumors of the brain, and skull base surgery.
Dr. Klinge has hosted the international conference “Hydrocephalus 2008” in Hannover, Germany and she was recently elected President of the International Society for Hydrocephalus and CSF Disorders. Dr. Klinge is also reviewer of various peer-reviewed journals in the field of clinical and experimental neurosurgery and neurology , and was recently appointed “Associated Editor of Clinical Neurology and Neurosurgery”.
Professional Papers
- Multiplicity of Cerebrospinal Fluid Functions: New Challenges in Health and Disease Conrad E. Johanson; John A. Duncan; Petra M. Klinge; Edward G. Stopa and Gerald PD. Silverberg. Cerebrospinal Fluid Research 2008
- Modified calcium accumulation after controlled cortical impact under cyclosporin A treatment: a (45)Ca autoradiographic study. Mirzayan MJ; Klinge PM; Ude S; Hotop A; Samii M; Brinker T; Korkmaz Z; Meyer GJ; Knapp WH; Samii A. Neurol Res. 2008
- Correlates of local cerebral blood flow (CBF) in normal pressure hydrocephalus patients before and after shunting-A retrospective analysis of [(15)O]H(2)O PET-CBF studies in 65 patients. Klinge PM; Brooks DJ; Samii A; Weckesser E; van den Hoff J; Fricke H; Brinker T; Knapp WH; Berding G. Clinical Neurol Neurosurg 2008
- A positron emission tomography study of cerebrovascular reserve before and after shunt surgery in patients with idiopathic chronic hydrocephalus. Klinge PM; Berding G; Brinker T; Knapp WH; Samii M. J Neurosurg. 1999 Oct; 91(4): 605-9.
- Outcome of shunting in idiopathic normal-pressure hydrocephalus and the value of outcome assessment in shunted patients. Klinge P; Marmarou A; Bergsneider M; Relkin N; Black PM. Neurosurgery. 2005 Sep; 57 (3 Suppl):S40-52
- Correlates of local cerebral blood flow (CBF) in normal pressure hydrocephalus patients before and after shunting-A retrospective analysis of [(15)O]H(2)O PET-CBF studies in 65 patients. Klinge PM; Brooks DJ; Samii A; Weckesser E; van den Hoff J; Fricke H; Brinker T; Knapp WH; Berding G. Clinical Neurol Neurosurg 2008
- Amyloid and Tau accumulate in the brains of aged hydrocephalic rats. Gerald D. Silverberg, Miles C. Miller, Jason T. Machan, Conrad E. Johanson, Ilias N. Caralopoulos, Crissey L. Pascale, Anna Heile, Petra M. Klinge. BRAIN RESEARCH 1317 (2010) 286 – 296
