Adam Chodobski, Ph.D. Research Interests

For many years, Dr. Chodobski has been interested in the role of neuropeptides—particularly angiotensin, atrial naturetic peptide, and vasopressin--in regulating fluid balance in the central nervous system. He has studied the effects of these peptides on CSF dynamics and blood flow regulation. Recently, he has focused on the choroid plexus as a source of, and target for, polypeptides, as well as its part in traumatic brain injury.

Dr. Chodobski’s current work emphasizes the role of centrally released neuropeptides, growth factors, and inflammatory cytokines in promoting the formation of cerebral edema. In research funded by the National Institute of Neurological Disorders and Stroke, he found a marked increase in the expression of vasopressin receptors in certain cell types, including astrocytes and cerebrovascular endothelial cells, after traumatic brain injury. His findings highlight vasopressin’s importance in the development of post-traumatic edema.

To pinpoint the molecular mechanisms by which vasopressin disrupts brain vascular barriers and fosters fluid buildup, Dr. Chodobski is studying its interactions with various growth factors and cytokines. The results may suggest potential targets for treating cerebral edema.